Data
SNB101 from AIMS bio science
- Individual concentration plots
- Mean+sd concentration plots
- Naive NCA results
- After administration (time >= 0)
- From the beginning of administration (time >= -2)
- Dose-normalized NCA results
- After administration (time >= 0)
- From the beginning of administration (time >= -2)
- Simple covariate analysis using correlation & linear regression
Plots are shown in interactive way Click the name (irinotecan, SN-38, SN-38G) on the label for the seperated view (Right side of the plot)
Individual concentration plots
Mean+sd concentration plot

Naive NCA results
NCA result with individual dose
After end of adminitration (time >= 0)
End of administration시점부터의 NCA 계산함 (time < 0는 분석에서 제외함)
Irinotecan
|
Subject
|
CMAX
|
TMAX
|
LAMZHL
|
AUCLST
|
AUCIFO
|
|
C1_01-001
|
70.61
|
0.0
|
5.725037
|
161.188
|
198.5126
|
|
C2_03-001
|
73.34
|
0.0
|
4.948905
|
381.790
|
396.9263
|
|
C3_02-002
|
229.40
|
0.5
|
24.534894
|
2548.050
|
2812.4609
|
|
C4_03-002
|
272.41
|
0.0
|
18.604625
|
1296.453
|
1353.3550
|
|
C4_02-003
|
721.77
|
0.5
|
11.479251
|
1570.610
|
1605.7194
|
|
C4_01-002
|
491.28
|
0.0
|
13.187731
|
2172.370
|
2212.7049
|
|
C4_01-003
|
271.76
|
0.0
|
9.436067
|
1385.737
|
1414.5978
|
|
C4_01-004
|
664.98
|
0.5
|
11.394901
|
2787.418
|
2822.2690
|
|
C5_02-004
|
459.54
|
0.0
|
11.239705
|
2171.032
|
2239.7861
|
|
C5_03-003
|
549.59
|
0.0
|
10.536213
|
2466.932
|
2531.3828
|
|
C5_01-006
|
485.88
|
0.0
|
9.955497
|
4205.870
|
4266.7680
|
|
C5_02-005
|
665.90
|
0.0
|
11.937573
|
7453.140
|
7526.1625
|
|
C5_02-006
|
669.55
|
0.0
|
9.880453
|
3215.610
|
3276.0490
|
|
C5_01-007
|
662.53
|
0.0
|
9.722780
|
5630.738
|
5690.2120
|
|
C5_03-004
|
436.79
|
0.0
|
10.274070
|
2385.870
|
2448.7168
|
|
C6_03-005
|
496.74
|
0.0
|
10.430611
|
2738.073
|
2801.8768
|
|
C6_02-007
|
959.88
|
0.0
|
11.021335
|
3649.655
|
3717.0728
|
SN-38
|
Subject
|
CMAX
|
TMAX
|
LAMZHL
|
AUCLST
|
AUCIFO
|
|
C1_01-001
|
144.502
|
0.0
|
4.392132
|
148.4135
|
157.2719
|
|
C2_03-001
|
96.280
|
0.0
|
2.409351
|
159.5100
|
163.5421
|
|
C3_02-002
|
124.610
|
0.5
|
17.823767
|
576.1425
|
594.3996
|
|
C4_03-002
|
322.940
|
0.5
|
95.303849
|
473.3325
|
654.8251
|
|
C4_02-003
|
579.240
|
0.0
|
6.284927
|
580.2775
|
594.6037
|
|
C4_01-002
|
747.660
|
0.0
|
13.018502
|
1141.2275
|
1154.5625
|
|
C4_01-003
|
526.530
|
0.0
|
19.188157
|
931.6800
|
951.3347
|
|
C4_01-004
|
1107.660
|
0.0
|
14.801469
|
1285.4300
|
1315.7527
|
|
C5_02-004
|
527.520
|
0.0
|
48.247269
|
956.3175
|
1054.4621
|
|
C5_03-003
|
722.620
|
0.0
|
5.465684
|
1134.9100
|
1146.0283
|
|
C5_01-006
|
682.590
|
0.0
|
24.641777
|
1958.4125
|
2008.5388
|
|
C5_02-005
|
909.970
|
0.0
|
78.245129
|
3370.0450
|
3529.2112
|
|
C5_02-006
|
863.380
|
0.0
|
13.163867
|
1070.5950
|
1097.3729
|
|
C5_01-007
|
820.140
|
0.0
|
10.526648
|
1314.6175
|
1336.0308
|
|
C5_03-004
|
396.940
|
0.0
|
8.313664
|
672.7125
|
689.6242
|
|
C6_03-005
|
419.370
|
0.0
|
3.694194
|
520.1200
|
527.6347
|
|
C6_02-007
|
1050.120
|
0.0
|
18.685614
|
1175.7600
|
1213.7703
|
SN-38G
|
Subject
|
CMAX
|
TMAX
|
LAMZHL
|
AUCLST
|
AUCIFO
|
|
C1_01-001
|
165.072
|
0.0
|
19.023959
|
637.1770
|
660.9176
|
|
C2_03-001
|
178.300
|
0.0
|
33.155656
|
649.5500
|
729.4319
|
|
C3_02-002
|
185.780
|
0.5
|
14.666856
|
963.3975
|
986.8849
|
|
C4_03-002
|
260.950
|
0.0
|
33.320084
|
1284.5450
|
1429.2379
|
|
C4_02-003
|
304.010
|
0.0
|
13.222703
|
1025.5200
|
1057.3775
|
|
C4_01-002
|
299.760
|
0.5
|
13.761658
|
1299.9775
|
1326.3832
|
|
C4_01-003
|
1296.700
|
0.0
|
54.601868
|
3898.9275
|
4002.1212
|
|
C4_01-004
|
1668.840
|
0.0
|
11.722381
|
3954.4775
|
3977.6467
|
|
C5_02-004
|
242.130
|
0.0
|
16.440958
|
1481.6650
|
1519.3787
|
|
C5_03-003
|
392.000
|
0.0
|
19.202091
|
1550.2125
|
1580.9626
|
|
C5_01-006
|
728.060
|
0.0
|
21.469494
|
5889.8375
|
5911.8290
|
|
C5_02-005
|
586.940
|
0.0
|
31.815546
|
4986.6950
|
5019.2841
|
|
C5_02-006
|
436.440
|
0.0
|
15.552769
|
1647.6325
|
1663.5634
|
|
C5_01-007
|
1214.940
|
0.0
|
9.344536
|
5354.1800
|
5383.5693
|
|
C5_03-004
|
1311.600
|
0.5
|
10.027999
|
3791.8175
|
3802.0893
|
|
C6_03-005
|
731.660
|
0.0
|
77.867546
|
1869.4250
|
1949.1858
|
|
C6_02-007
|
444.990
|
0.0
|
13.289757
|
1956.7900
|
1970.4029
|
Summary
| Parameter |
irinotecan, N = 17 |
SN-38, N = 17 |
SN-38G, N = 17 |
| CMAX |
481.291 ± 239.339 |
590.710 ± 312.784 |
614.598 ± 474.079 |
| LAMZHL |
11.430 ± 4.444 |
22.600 ± 26.625 |
24.029 ± 18.090 |
| AUCLST |
2,718.855 ± 1,805.316 |
1,027.618 ± 757.709 |
2,484.813 ± 1,754.701 |
| AUCIFO |
2,783.210 ± 1,815.559 |
1,069.939 ± 783.684 |
2,527.663 ± 1,748.679 |
From the beginning of administration (time >= -2)
용량 주입 시점 (time = -2) 부터의 NCA를 계산함 (Continuous infusion, duration은 2hr 로 설정)
Irinotecan
|
Subject
|
CMAX
|
TMAX
|
LAMZHL
|
AUCLST
|
AUCIFO
|
|
C1_01-001
|
70.61
|
0.0
|
5.725037
|
161.188
|
198.5126
|
|
C2_03-001
|
73.34
|
0.0
|
4.948905
|
381.790
|
396.9263
|
|
C3_02-002
|
229.40
|
0.5
|
24.534894
|
2548.050
|
2812.4609
|
|
C4_03-002
|
272.41
|
0.0
|
18.604625
|
1296.453
|
1353.3550
|
|
C4_02-003
|
721.77
|
0.5
|
11.479251
|
1570.610
|
1605.7194
|
|
C4_01-002
|
491.28
|
0.0
|
13.187731
|
2172.370
|
2212.7049
|
|
C4_01-003
|
271.76
|
0.0
|
9.436067
|
1385.737
|
1414.5978
|
|
C4_01-004
|
664.98
|
0.5
|
11.394901
|
2787.418
|
2822.2690
|
|
C5_02-004
|
459.54
|
0.0
|
11.239705
|
2171.032
|
2239.7861
|
|
C5_03-003
|
549.59
|
0.0
|
10.536213
|
2466.932
|
2531.3828
|
|
C5_01-006
|
485.88
|
0.0
|
9.955497
|
4205.870
|
4266.7680
|
|
C5_02-005
|
665.90
|
0.0
|
11.937573
|
7453.140
|
7526.1625
|
|
C5_02-006
|
669.55
|
0.0
|
9.880453
|
3215.610
|
3276.0490
|
|
C5_01-007
|
662.53
|
0.0
|
9.722780
|
5630.738
|
5690.2120
|
|
C5_03-004
|
436.79
|
0.0
|
10.274070
|
2385.870
|
2448.7168
|
|
C6_03-005
|
496.74
|
0.0
|
10.430611
|
2738.073
|
2801.8768
|
|
C6_02-007
|
959.88
|
0.0
|
11.021335
|
3649.655
|
3717.0728
|
SN-38
|
Subject
|
CMAX
|
TMAX
|
LAMZHL
|
AUCLST
|
AUCIFO
|
|
C1_01-001
|
144.502
|
0.0
|
4.392132
|
148.4135
|
157.2719
|
|
C2_03-001
|
96.280
|
0.0
|
2.409351
|
159.5100
|
163.5421
|
|
C3_02-002
|
124.610
|
0.5
|
17.823767
|
576.1425
|
594.3996
|
|
C4_03-002
|
322.940
|
0.5
|
95.303849
|
473.3325
|
654.8251
|
|
C4_02-003
|
579.240
|
0.0
|
6.284927
|
580.2775
|
594.6037
|
|
C4_01-002
|
747.660
|
0.0
|
13.018502
|
1141.2275
|
1154.5625
|
|
C4_01-003
|
526.530
|
0.0
|
19.188157
|
931.6800
|
951.3347
|
|
C4_01-004
|
1107.660
|
0.0
|
14.801469
|
1285.4300
|
1315.7527
|
|
C5_02-004
|
527.520
|
0.0
|
48.247269
|
956.3175
|
1054.4621
|
|
C5_03-003
|
722.620
|
0.0
|
5.465684
|
1134.9100
|
1146.0283
|
|
C5_01-006
|
682.590
|
0.0
|
24.641777
|
1958.4125
|
2008.5388
|
|
C5_02-005
|
909.970
|
0.0
|
78.245129
|
3370.0450
|
3529.2112
|
|
C5_02-006
|
863.380
|
0.0
|
13.163867
|
1070.5950
|
1097.3729
|
|
C5_01-007
|
820.140
|
0.0
|
10.526648
|
1314.6175
|
1336.0308
|
|
C5_03-004
|
396.940
|
0.0
|
8.313664
|
672.7125
|
689.6242
|
|
C6_03-005
|
419.370
|
0.0
|
3.694194
|
520.1200
|
527.6347
|
|
C6_02-007
|
1050.120
|
0.0
|
18.685614
|
1175.7600
|
1213.7703
|
SN-38G
|
Subject
|
CMAX
|
TMAX
|
LAMZHL
|
AUCLST
|
AUCIFO
|
|
C1_01-001
|
165.072
|
0.0
|
19.023959
|
637.1770
|
660.9176
|
|
C2_03-001
|
178.300
|
0.0
|
33.155656
|
649.5500
|
729.4319
|
|
C3_02-002
|
185.780
|
0.5
|
14.666856
|
963.3975
|
986.8849
|
|
C4_03-002
|
260.950
|
0.0
|
33.320084
|
1284.5450
|
1429.2379
|
|
C4_02-003
|
304.010
|
0.0
|
13.222703
|
1025.5200
|
1057.3775
|
|
C4_01-002
|
299.760
|
0.5
|
13.761658
|
1299.9775
|
1326.3832
|
|
C4_01-003
|
1296.700
|
0.0
|
54.601868
|
3898.9275
|
4002.1212
|
|
C4_01-004
|
1668.840
|
0.0
|
11.722381
|
3954.4775
|
3977.6467
|
|
C5_02-004
|
242.130
|
0.0
|
16.440958
|
1481.6650
|
1519.3787
|
|
C5_03-003
|
392.000
|
0.0
|
19.202091
|
1550.2125
|
1580.9626
|
|
C5_01-006
|
728.060
|
0.0
|
21.469494
|
5889.8375
|
5911.8290
|
|
C5_02-005
|
586.940
|
0.0
|
31.815546
|
4986.6950
|
5019.2841
|
|
C5_02-006
|
436.440
|
0.0
|
15.552769
|
1647.6325
|
1663.5634
|
|
C5_01-007
|
1214.940
|
0.0
|
9.344536
|
5354.1800
|
5383.5693
|
|
C5_03-004
|
1311.600
|
0.5
|
10.027999
|
3791.8175
|
3802.0893
|
|
C6_03-005
|
731.660
|
0.0
|
77.867546
|
1869.4250
|
1949.1858
|
|
C6_02-007
|
444.990
|
0.0
|
13.289757
|
1956.7900
|
1970.4029
|
Summary
| Parameter |
irinotecan, N = 17 |
SN-38, N = 17 |
SN-38G, N = 17 |
| CMAX |
481.291 ± 239.339 |
590.710 ± 312.784 |
614.598 ± 474.079 |
| LAMZHL |
11.430 ± 4.444 |
22.600 ± 26.625 |
24.029 ± 18.090 |
| AUCLST |
2,718.855 ± 1,805.316 |
1,027.618 ± 757.709 |
2,484.813 ± 1,754.701 |
| AUCIFO |
2,783.210 ± 1,815.559 |
1,069.939 ± 783.684 |
2,527.663 ± 1,748.679 |
Dose-normalized NCA results
After administration (time >= 0)
Irinotecan
|
Subject
|
Dose
|
CMAX_dn
|
AUCLST_dn
|
AUCIFO_dn
|
|
C1_01-001
|
8.4
|
8.405952
|
19.18905
|
23.63245
|
|
C2_03-001
|
17.6
|
4.167046
|
21.69261
|
22.55263
|
|
C3_02-002
|
30.9
|
7.423948
|
82.46116
|
91.01815
|
|
C4_03-002
|
49.6
|
5.492137
|
26.13816
|
27.28538
|
|
C4_02-003
|
50.4
|
14.320833
|
31.16290
|
31.85951
|
|
C4_01-002
|
46.5
|
10.565161
|
46.71763
|
47.58505
|
|
C4_01-003
|
47.7
|
5.697275
|
29.05110
|
29.65614
|
|
C4_01-004
|
47.4
|
14.029114
|
58.80628
|
59.54154
|
|
C5_02-004
|
50.3
|
9.135984
|
43.16168
|
44.52855
|
|
C5_03-003
|
49.9
|
11.013828
|
49.43753
|
50.72911
|
|
C5_01-006
|
68.0
|
7.145294
|
61.85103
|
62.74659
|
|
C5_02-005
|
65.2
|
10.213190
|
114.31196
|
115.43194
|
|
C5_02-006
|
77.1
|
8.684176
|
41.70700
|
42.49091
|
|
C5_01-007
|
60.4
|
10.969040
|
93.22413
|
94.20881
|
|
C5_03-004
|
57.7
|
7.570017
|
41.34957
|
42.43877
|
|
C6_03-005
|
83.6
|
5.941866
|
32.75206
|
33.51527
|
|
C6_02-007
|
74.5
|
12.884295
|
48.98866
|
49.89359
|
SN-38
|
Subject
|
Dose
|
CMAX_dn
|
AUCLST_dn
|
AUCIFO_dn
|
|
C1_01-001
|
8.4
|
17.202619
|
17.668274
|
18.722850
|
|
C2_03-001
|
17.6
|
5.470454
|
9.063068
|
9.292165
|
|
C3_02-002
|
30.9
|
4.032686
|
18.645388
|
19.236234
|
|
C4_03-002
|
49.6
|
6.510887
|
9.542994
|
13.202119
|
|
C4_02-003
|
50.4
|
11.492857
|
11.513443
|
11.797693
|
|
C4_01-002
|
46.5
|
16.078710
|
24.542527
|
24.829302
|
|
C4_01-003
|
47.7
|
11.038365
|
19.532076
|
19.944123
|
|
C4_01-004
|
47.4
|
23.368354
|
27.118776
|
27.758495
|
|
C5_02-004
|
50.3
|
10.487475
|
19.012276
|
20.963461
|
|
C5_03-003
|
49.9
|
14.481363
|
22.743687
|
22.966499
|
|
C5_01-006
|
68.0
|
10.038088
|
28.800184
|
29.537335
|
|
C5_02-005
|
65.2
|
13.956595
|
51.687807
|
54.129007
|
|
C5_02-006
|
77.1
|
11.198184
|
13.885798
|
14.233112
|
|
C5_01-007
|
60.4
|
13.578477
|
21.765190
|
22.119715
|
|
C5_03-004
|
57.7
|
6.879376
|
11.658796
|
11.951892
|
|
C6_03-005
|
83.6
|
5.016388
|
6.221531
|
6.311420
|
|
C6_02-007
|
74.5
|
14.095570
|
15.782013
|
16.292219
|
SN-38G
|
Subject
|
Dose
|
CMAX_dn
|
AUCLST_dn
|
AUCIFO_dn
|
|
C1_01-001
|
8.4
|
19.651429
|
75.85440
|
78.68067
|
|
C2_03-001
|
17.6
|
10.130682
|
36.90625
|
41.44500
|
|
C3_02-002
|
30.9
|
6.012298
|
31.17791
|
31.93802
|
|
C4_03-002
|
49.6
|
5.261089
|
25.89808
|
28.81528
|
|
C4_02-003
|
50.4
|
6.031944
|
20.34762
|
20.97971
|
|
C4_01-002
|
46.5
|
6.446452
|
27.95651
|
28.52437
|
|
C4_01-003
|
47.7
|
27.184486
|
81.73852
|
83.90191
|
|
C4_01-004
|
47.4
|
35.207595
|
83.42780
|
83.91660
|
|
C5_02-004
|
50.3
|
4.813718
|
29.45656
|
30.20634
|
|
C5_03-003
|
49.9
|
7.855711
|
31.06638
|
31.68262
|
|
C5_01-006
|
68.0
|
10.706765
|
86.61526
|
86.93866
|
|
C5_02-005
|
65.2
|
9.002147
|
76.48305
|
76.98288
|
|
C5_02-006
|
77.1
|
5.660700
|
21.37007
|
21.57670
|
|
C5_01-007
|
60.4
|
20.114901
|
88.64536
|
89.13194
|
|
C5_03-004
|
57.7
|
22.731369
|
65.71607
|
65.89410
|
|
C6_03-005
|
83.6
|
8.751914
|
22.36154
|
23.31562
|
|
C6_02-007
|
74.5
|
5.973020
|
26.26564
|
26.44836
|
Summary
| Parameter |
irinotecan, N = 17 |
SN-38, N = 17 |
SN-38G, N = 17 |
| Dose |
52.071 ± 19.816 |
52.071 ± 19.816 |
52.071 ± 19.816 |
| CMAX_dn |
9.039 ± 3.009 |
11.466 ± 5.026 |
12.443 ± 9.094 |
| AUCLST_dn |
49.530 ± 26.084 |
19.364 ± 10.550 |
48.899 ± 27.334 |
| AUCIFO_dn |
51.124 ± 26.551 |
20.193 ± 10.847 |
50.022 ± 27.332 |
From the beginning of administration (time >= -2)
Irinotecan
|
Subject
|
Dose
|
CMAX_dn
|
AUCLST_dn
|
AUCIFO_dn
|
|
C1_01-001
|
8.4
|
8.405952
|
19.18905
|
23.63245
|
|
C2_03-001
|
17.6
|
4.167046
|
21.69261
|
22.55263
|
|
C3_02-002
|
30.9
|
7.423948
|
82.46116
|
91.01815
|
|
C4_03-002
|
49.6
|
5.492137
|
26.13816
|
27.28538
|
|
C4_02-003
|
50.4
|
14.320833
|
31.16290
|
31.85951
|
|
C4_01-002
|
46.5
|
10.565161
|
46.71763
|
47.58505
|
|
C4_01-003
|
47.7
|
5.697275
|
29.05110
|
29.65614
|
|
C4_01-004
|
47.4
|
14.029114
|
58.80628
|
59.54154
|
|
C5_02-004
|
50.3
|
9.135984
|
43.16168
|
44.52855
|
|
C5_03-003
|
49.9
|
11.013828
|
49.43753
|
50.72911
|
|
C5_01-006
|
68.0
|
7.145294
|
61.85103
|
62.74659
|
|
C5_02-005
|
65.2
|
10.213190
|
114.31196
|
115.43194
|
|
C5_02-006
|
77.1
|
8.684176
|
41.70700
|
42.49091
|
|
C5_01-007
|
60.4
|
10.969040
|
93.22413
|
94.20881
|
|
C5_03-004
|
57.7
|
7.570017
|
41.34957
|
42.43877
|
|
C6_03-005
|
83.6
|
5.941866
|
32.75206
|
33.51527
|
|
C6_02-007
|
74.5
|
12.884295
|
48.98866
|
49.89359
|
SN-38
|
Subject
|
Dose
|
CMAX_dn
|
AUCLST_dn
|
AUCIFO_dn
|
|
C1_01-001
|
8.4
|
17.202619
|
17.668274
|
18.722850
|
|
C2_03-001
|
17.6
|
5.470454
|
9.063068
|
9.292165
|
|
C3_02-002
|
30.9
|
4.032686
|
18.645388
|
19.236234
|
|
C4_03-002
|
49.6
|
6.510887
|
9.542994
|
13.202119
|
|
C4_02-003
|
50.4
|
11.492857
|
11.513443
|
11.797693
|
|
C4_01-002
|
46.5
|
16.078710
|
24.542527
|
24.829302
|
|
C4_01-003
|
47.7
|
11.038365
|
19.532076
|
19.944123
|
|
C4_01-004
|
47.4
|
23.368354
|
27.118776
|
27.758495
|
|
C5_02-004
|
50.3
|
10.487475
|
19.012276
|
20.963461
|
|
C5_03-003
|
49.9
|
14.481363
|
22.743687
|
22.966499
|
|
C5_01-006
|
68.0
|
10.038088
|
28.800184
|
29.537335
|
|
C5_02-005
|
65.2
|
13.956595
|
51.687807
|
54.129007
|
|
C5_02-006
|
77.1
|
11.198184
|
13.885798
|
14.233112
|
|
C5_01-007
|
60.4
|
13.578477
|
21.765190
|
22.119715
|
|
C5_03-004
|
57.7
|
6.879376
|
11.658796
|
11.951892
|
|
C6_03-005
|
83.6
|
5.016388
|
6.221531
|
6.311420
|
|
C6_02-007
|
74.5
|
14.095570
|
15.782013
|
16.292219
|
SN-38G
|
Subject
|
Dose
|
CMAX_dn
|
AUCLST_dn
|
AUCIFO_dn
|
|
C1_01-001
|
8.4
|
19.651429
|
75.85440
|
78.68067
|
|
C2_03-001
|
17.6
|
10.130682
|
36.90625
|
41.44500
|
|
C3_02-002
|
30.9
|
6.012298
|
31.17791
|
31.93802
|
|
C4_03-002
|
49.6
|
5.261089
|
25.89808
|
28.81528
|
|
C4_02-003
|
50.4
|
6.031944
|
20.34762
|
20.97971
|
|
C4_01-002
|
46.5
|
6.446452
|
27.95651
|
28.52437
|
|
C4_01-003
|
47.7
|
27.184486
|
81.73852
|
83.90191
|
|
C4_01-004
|
47.4
|
35.207595
|
83.42780
|
83.91660
|
|
C5_02-004
|
50.3
|
4.813718
|
29.45656
|
30.20634
|
|
C5_03-003
|
49.9
|
7.855711
|
31.06638
|
31.68262
|
|
C5_01-006
|
68.0
|
10.706765
|
86.61526
|
86.93866
|
|
C5_02-005
|
65.2
|
9.002147
|
76.48305
|
76.98288
|
|
C5_02-006
|
77.1
|
5.660700
|
21.37007
|
21.57670
|
|
C5_01-007
|
60.4
|
20.114901
|
88.64536
|
89.13194
|
|
C5_03-004
|
57.7
|
22.731369
|
65.71607
|
65.89410
|
|
C6_03-005
|
83.6
|
8.751914
|
22.36154
|
23.31562
|
|
C6_02-007
|
74.5
|
5.973020
|
26.26564
|
26.44836
|
Summary
| Parameter |
irinotecan, N = 17 |
SN-38, N = 17 |
SN-38G, N = 17 |
| Dose |
52.071 ± 19.816 |
52.071 ± 19.816 |
52.071 ± 19.816 |
| CMAX_dn |
9.039 ± 3.009 |
11.466 ± 5.026 |
12.443 ± 9.094 |
| AUCLST_dn |
49.530 ± 26.084 |
19.364 ± 10.550 |
48.899 ± 27.334 |
| AUCIFO_dn |
51.124 ± 26.551 |
20.193 ± 10.847 |
50.022 ± 27.332 |
Simple covariate analysis using correlation & linear regression
Correlation plot

Linear regression (Univariate) result
| Characteristic |
LAMZHL
|
CMAX_dn
|
AUCLST_dn
|
| Beta |
95% CI |
p-value |
Beta |
95% CI |
p-value |
Beta |
95% CI |
p-value |
| sex |
|
|
|
|
|
|
|
|
|
| 남성 |
— |
— |
|
— |
— |
|
— |
— |
|
| 여성 |
7.8 |
-13, 28 |
0.45 |
-6.8 |
-13, -0.17 |
0.045 |
-4.4 |
-33, 24 |
0.76 |
| age |
0.37 |
-0.38, 1.1 |
0.33 |
-0.03 |
-0.27, 0.21 |
0.79 |
0.40 |
-0.64, 1.4 |
0.44 |
| WT |
0.53 |
-1.9, 3.0 |
0.66 |
0.60 |
-0.19, 1.4 |
0.13 |
1.1 |
-2.3, 4.5 |
0.52 |
| BSA |
-16 |
-202, 170 |
0.86 |
-53 |
-113, 6.5 |
0.079 |
-96 |
-354, 162 |
0.46 |
Simple distribution for categorical variable (sex)